Spaeth is sidelined with a deep thigh bruise.
Also inactive for the Steelers are wide receiver Willie Reid, cornerback Ricardo Colclough, running back Gary Russell, linebacker Andre Frazier, guard/center Darnell Stapleton, offensive tackle Trai Essex and quarterback Brian St. Pierre.
Among the inactives for the 49ers is starting outside linebacker Manny Lawson. Lawson sustained a season-ending knee injury in practice last week.
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